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Parallel microbial imbalance extends to respiratory ecosystems, where asthma severity correlates positively with reduced bacterial diversity and elevated proteobacterial abundance in the airway microbiome (Liao et al., 2022

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Early evidence linking stress to hippocampal synaptic plasticity came from electrophysiological studies showing that intermittent tail shock during restraint significantly impaired LTP in the Schaffer collateral-commissural pathway to the cornu ammonis 1 (CA1) region in rat hippocampal slices ( Although chronically elevated cortisol is often considered detrimental, insufficient glucocorticoid signaling may also impair synaptic plasticity