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Demonstration of a hyperglycemia-driven pathogenic abnormality of copper homeostasis in diabetes and its reversibility by selective chelation: quantitative comparisons between the biology of copper and eight other nutritionally essential elements in normal and diabetic individuals

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This alteration of FA metabolism regulators is a part of the so-called fetal reprogramming that is a well-known hallmark of HF [134] and is characterized by a switch of substrate preference of cardiomyocytes to carbohydrates, as is the case in the immature heart [135]

Furthermore, PCYT1A knockdown induced the formation of larger LDs in FA-rich cultural medium (Fig

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