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Notably, AUD patients treated with spironolactone reported less alcohol use compared to those not receiving treatment (linear drinking score of 3.2 in treated group versus 3.9 in the untreated group, p =0.02)

Proteomic profiling further reveals that the cargo composition of erythrocytederived EVs correlates with disease severity, suggesting a potential link between vesicle content and functional impact in the brain [31]

Human studies further corroborate these findings

H.MengL.LiX

Preparation of calibration and quality control samples The analyte stock solution containing 25 target amino acids and the internal standard (IS) stock solution containing five isotopically labeled amino acids were prepared in 0.1 M HCl