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In laboratory models, it stimulates the pituitary glands release of growth hormone without significantly triggering the release of cortisol, prolactin, or ACTH, which makes it a highly selective research tool compared to earlier-generation secretagogues

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The Effects of Heme Oxygenase Upregulation on Obesity and the Metabolic Syndrome

References 1.American Association of Clinical Endocrinologists Growth Hormone Task Force

IGF-1 DES binds IGFBP-3 poorly, similar to LR3, but it also has roughly ten-fold higher potency at IGF-1R because the N-terminal tripeptide normally dampens receptor-binding affinity

Khorram, O., Laughlin, G