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Pre-treatment with allopurinol (a xanthine oxidase inhibitor) or dimethyl sulfoxide (DMSO) (a hydroxyl free radical scavenger) can block the apoptotic activity induced by smoking, and does not affect the p53 level of the mucosa (26), suggesting that the apoptosis induced by cigarette smoking is mediated through reactive oxygen species (ROS) and occurs independently of the p53 pathway

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Careful, sustained investigation is critical

We have seen a strong association between smoking and young heart attacks," says Dr

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Some results presented in Table 2 are consistent with those presented by Goldstein and Bearman (Reference Goldstein and Bearman1996)