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Symptomatic skin changes that are part of patient-related complaints mostly include localized or generalized hyperpigmentation and darkening over face or body parts

Challenges include an acidic microclimate inducing protein aggregation (neutralization with MgCO3), incomplete release of hydrophilics, and scale-up variability

Cornea and skin Sosne (2011) documented the effect of TB-500 on corneal healing (corneal ulcer and alkali burn models)

PMCID: PMC8332470

Aflatoxins can affect kidney function, leading to nephrotoxicity and chronic kidney disease (CKD) in severe cases

Clinical data in humans remain limited, highlighting the need for further well-designed clinical research to establish both safety and efficacy