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Thus, a better molecular understanding of signals and mediators in regenerative tissue responses and resolution of metabolic injuries is critical to develop clinically-relevant therapeutic interventions focusing on the enforcement of epithelial regenerative capacity by improving metabolic fitness, a novel strategy for combating intestinal diseases

However, the Wolff-Chaikoff effect is transient, usually lasting only one to two days, after which an escape occurs where regular synthesis of thyroid hormones resumes (25, 27, 31)