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Compared to previously established LSM based cutoff values of 10.5 kPa (Youden index) and 13.3 kPa (maximized specificity), the false positive rates of sequential covering analysis was 1% compared to 16.5% with LSM 10.5 kPa and 8.3% with LSM 13.3 kPa

The method focused on the label-free quantitation of 21 key metabolites, encompassing intact glutathione and other thiols, their oxidized forms, precursor amino acids, and related sulfur-containing compounds

10.1053/j.gastro.2013.09.046 Gastroenterology 77 HalvorsonH

Its advisable to commence with a conservative dosage and gradually adjust based on individual response and tolerance levels

Overall, the studies evaluated both efficacy, through clinical and biological outcomes, and safety, mainly in terms of tolerability

The default works for most peptides but not all