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doi: 10.52305/WILY1027 199 ZiaeiSHasaniMMalekahmadiMDaneshzadEKadkhodazadehKHeshmatiJ

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Dihydroartemisinin decreases GPX4, FTH1, and NCOA4 expression and reduces Fe 2+ levels by inhibiting the PRIM2/SLC7A11 axis (YU, 2021

[47] The importance of regulating the conversion of pyruvate into acetyl-CoA is also underscored by the fact that mammals, although able to produce glucose from pyruvate, cannot synthesize it from acetyl-CoA because of the irreversibility of the pyruvate dehydrogenase reaction and the absence of alternative pathways